Key result
Reducing Ca2+ activation levels progressively decreased peak absolute and relative power outputs and slowed shortening velocities in rat cardiac myocytes and skeletal muscle fibres.
Reduced calcium activation levels progressively decrease loaded shortening velocity and power output in rat cardiac and skeletal muscle fibers, likely due to cooperative inactivation of the thin filament.
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Reduced Ca2+ activation impairs myocyte power; extends cross-fiber mechanisms but leaves open disease relevance.
Kerry S. McDonald (2000) studied this question. Reduced Ca2+ activation levels vs. Maximal Ca2+ activation was evaluated on Loaded shortening and power output. Reducing Ca2+ activation levels progressively decreased peak absolute and relative power outputs and slowed shortening velocities in rat cardiac myocytes and skeletal muscle fibres.
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