Key result
Osmotic compression with 5% dextran caused a marked decrease in maximum shortening velocity in the high-velocity phase when thin filament activation was varied over a wide range.
Osmotic compression of skinned rat skeletal muscle fibers reveals that cross-bridges in expanded filament lattices may buckle during shortening rather than bearing axial compressive force.
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Hypothesis-generating for Ca2+-dependent Vmax control in slow fibres; leaves open cardiac translation.
Metzger et al. (1988) studied this question. Osmotic compression induced by 5% dextran vs. Absence of dextran was evaluated on Maximum shortening velocity (Vmax). Osmotic compression with 5% dextran caused a marked decrease in maximum shortening velocity in the high-velocity phase when thin filament activation was varied over a wide range.
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