Key result
Heterozygous familial hypobetalipoproteinemia was associated with a 75% decrease in VLDL apoB production rates (5.8 vs 23.4 mg/kg per day, P<0.001) compared with healthy normolipidemic subjects.
Why the study?
Are the production rates of VLDL triglycerides and VLDL apoB-100 decreased in subjects heterozygous for Familial Hypobetalipoproteinemia compared to healthy controls?
Observational (n=14)
Are the production rates of VLDL triglycerides and VLDL apoB-100 decreased in subjects heterozygous for Familial Hypobetalipoproteinemia compared to healthy controls?
Effect estimate: 75% decrease
Absolute Event Rate: 5.8% vs 23.4%
p-value: p=<0.001
Heterozygotes for familial hypobetalipoproteinemia have significantly reduced hepatic secretion of both VLDL apoB and VLDL triglycerides, though the reduction in triglycerides is less pronounced, suggesting secretion of triglyceride-enriched VLDL particles.
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VLDL TG production reduced 60% in FHBL; extends apoB kinetics data but leaves open clinical implications pending larger studies.
Elias et al. (1999) conducted an observational in Familial hypobetalipoproteinemia (n=14). Heterozygous familial hypobetalipoproteinemia (FHBL) vs. Healthy normolipidemic subjects was evaluated on VLDL apoB production rates (mg/kg per day) (75% decrease, p=<0.001). Heterozygous familial hypobetalipoproteinemia was associated with a 75% decrease in VLDL apoB production rates (5.8 vs 23.4 mg/kg per day, P<0.001) compared with healthy normolipidemic subjects.
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