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November 14, 2008DiabetesOpen Access

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway

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Authors

JLJi‐Hyun LeeMSMi‐Young SongESEunkyung Song

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Lee et al. (2008) studied this question.

synapsesocial.com/papers/6a6ba75226cff2e2f6f474b1https://doi.org/10.2337/db07-1795
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  1. 1Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice2007 · 322 citations
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  3. 3Basal expression of cyclooxygenase-2 and nuclear factor–interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet1998 · 141 citations
  4. 4The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.2000 · 211 citations
  5. 5Cytokines activate the nuclear factor κB (NF‐κB) and induce nitric oxide production in human pancreatic islets1996 · 107 citations