Key result
Musculoskeletal surgery and undergoing two or more surgeries were associated with a higher risk of dementia compared to controls (HR 1.44; 95% CI 1.22-1.70 and HR 1.42; 95% CI 1.17-1.72, respectively).
Why the study?
The relationship between dementia and surgery remains unclear, research on the topic is scarce, and epidemiological investigations are complicated.
Does musculoskeletal surgery or multiple surgeries increase the risk of dementia in a nationwide cohort?
Cohort
Yes
Does musculoskeletal surgery or multiple surgeries increase the risk of dementia in a nationwide cohort?
Hazard Ratio: 1.44 (95% CI 1.22–1.7)
Absolute Event Rate: 13.47% vs 9.66%
Musculoskeletal surgery and undergoing two or more surgeries are associated with a significantly increased risk of developing dementia compared to controls.
May associate surgery type with dementia incidence; leaves open causal effects and practice change.
The relationship between dementia and surgery remains unclear. Research to elucidate the relationship between them is scarce, and conducting epidemiological research is complicated. This study aimed to investigate the incidence and risk of dementia according to the surgery type. We performed a retrospective propensity score-matched cohort study using nationwide representative cohort sample data from the Korean National Health Insurance Service in South Korea between 2003 and 2004. Incidence rates for dementia were obtained by dividing the number of patients with dementia by person-years at risk. To identify the risk of dementia according to the type of surgery, we investigated the hazard ratio by each surgery type. The incidence rates of dementia in control, musculoskeletal, and two or more surgeries groups were 9.66, 13.47, and 13.36 cases per 1000 person-years, respectively. The risk of dementia in the musculoskeletal and two or more surgeries groups was 1.44-fold higher (95% confidence interval (95% CI), 1.22-1.70) and 1.42-fold higher (95% CI, 1.17-1.72) than that in the control group, respectively. Patients who underwent musculoskeletal surgery and two or more surgeries had a higher risk of dementia; however, there was no association with the type of anesthesia administered.
No takes yet. Share an insight, caveat, or question.
Kwon et al. (2022) conducted a cohort in dementia. Musculoskeletal surgery vs. Control group was evaluated on incidence of dementia (HR 1.44, 95% CI 1.22-1.70). Musculoskeletal surgery and undergoing two or more surgeries were associated with a higher risk of dementia compared to controls (HR 1.44; 95% CI 1.22-1.70 and HR 1.42; 95% CI 1.17-1.72, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: