Key result
Vascular geometry and its influence on local flow properties are the primary determinants of hemodynamic effects on the arterial wall and the initiation of atherosclerosis.
This review highlights the critical role of vascular geometry and local fluid mechanics in the localization and initiation of atherosclerosis.
Vascular geometry may primarily determine hemodynamic effects on atherogenesis; leaves open prospective validation before clinical translation.
The evidence for a hemodynamic involvement and possible mechanisms by which hemodynamic-related events could influence the arterial wall, and in particular the vascular endothelium, are reviewed and used to speculate on the role of fluid mechanics in atherogenesis and specifically in lesion localization. The evidence presented suggests that it is vascular geometry, and the way it influences the local detailed flow properties, which is the primary determinant of a hemodynamic effect on the arterial wall and in the initiation of atherosclerosis.
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Robert M. Nerem (1984) conducted a review in Atherogenesis. Hemodynamics and vascular geometry was evaluated. Vascular geometry and its influence on local flow properties are the primary determinants of hemodynamic effects on the arterial wall and the initiation of atherosclerosis.
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