Key result
Continued use of ACE inhibitors after a first angioedema episode was associated with a higher recurrence rate compared to discontinuation (18.7 vs 1.8 per 100 patient-years; P=.001).
Why the study?
Does continued use of ACE inhibitors increase the risk of recurrent angioedema in patients with a prior episode?
Population
82 Medicaid enrollees aged 15 years or older who used an ACE inhibitor and had a first documented episode of…
Comparison
Continued use of ACE inhibitors vs Discontinued use of ACE inhibitors
Design
Cohort
Follow-up
189 patient-years of follow-up (through June 1993)
Authors
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Continued ACE inhibitor use after angioedema may carry unrecognized recurrence risk; leaves open optimal discontinuation strategies pending prospective data.
Cohort (n=82)
Does continued use of ACE inhibitors increase the risk of recurrent angioedema in patients with a prior episode?
Absolute Event Rate: 18.7% vs 1.8%
p-value: p=.001
Continuing ACE inhibitors after an initial episode of angioedema significantly increases the risk of recurrence, highlighting the need for prompt recognition and discontinuation.
Nancy J. Brown (1997) conducted a cohort in ACE inhibitor-associated angioedema (n=82). Continued use of ACE inhibitors vs. Discontinued use of ACE inhibitors was evaluated on recurrent episodes of angioedema (p=.001). Continued use of ACE inhibitors after a first angioedema episode was associated with a higher recurrence rate compared to discontinuation (18.7 vs 1.8 per 100 patient-years; P=.001).
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