June 1, 2000European Journal of Heart Failure
Left Ventricular-Based Pacing in Patients with Chronic Heart Failure: Comparison of Acute Hemodynamic Benefits According to Underlying Heart Disease
Key result
Patients with dilated and ischemic cardiomyopathy showed similar improvements in pulmonary capillary wedge pressure (-16% vs -14%) during acute left ventricular-based pacing.
Why the study?
Does the underlying heart disease (dilated vs. ischemic cardiomyopathy) influence the acute hemodynamic benefits of left ventricular-based pacing in patients with severe heart failure and LBBB?
Population
46 patients with severe chronic heart failure and left bundle branch block, separated into dilated…
Comparison
Acute left ventricular-based pacing and… vs Baseline hemodynamics and comparison between…
Design
Cohort
Follow-up
Acute
Authors
Discussion
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Implication
Acute LV pacing effects in severe HF with LBBB appear etiology-independent; leaves open long-term efficacy and selection criteria.
Study Design
Type
Cohort (n=46)
Structured PICO
Does the underlying heart disease (dilated vs. ischemic cardiomyopathy) influence the acute hemodynamic benefits of left ventricular-based pacing in patients with severe heart failure and LBBB?
P
Population
46 patients with severe heart failure and LBBB (25 with dilated and 21 with ischemic cardiomyopathy) evaluated for acute hemodynamic responses to left ventricular-based pacing.
E
Exposure
Acute left ventricular-based pacing and biventricular pacing
C
Comparator
Baseline hemodynamics (no pacing) and comparison between dilated vs. ischemic cardiomyopathy groups
O
Outcome
Acute changes in hemodynamic parameters (pulmonary capillary wedge pressure and V wave amplitude)surrogate
Main Result
Absolute Event Rate: -16% vs -14%
Underlying heart disease etiology (dilated vs. ischemic) does not significantly influence the acute hemodynamic benefits of left ventricular-based pacing in patients with severe heart failure and LBBB.
Cite This Study
Mansourati et al. (2000) conducted a cohort in Severe chronic heart failure and left bundle branch block (n=46). Dilated cardiomyopathy vs. Ischemic cardiomyopathy was evaluated on Change in pulmonary capillary wedge pressure during acute left ventricular pacing. Patients with dilated and ischemic cardiomyopathy showed similar improvements in pulmonary capillary wedge pressure (-16% vs -14%) during acute left ventricular-based pacing.