Key result
The ACTN3 R577X polymorphism was not associated with differences in power output, fatigability, or force-velocity characteristics in moderately trained individuals.
Why the study?
Does the ACTN3 R577X genotype influence muscle power, strength, and fatigability in moderately to well-trained individuals?
Population
120 moderately to well-trained men and women (with a subset of 21 men performing isokinetic exercise)
Design
Cross-sectional
Authors
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ACTN3 R577X was associated with sprint performance; leaves open its role in muscle function or disease.
Cross-Sectional (n=120)
Does the ACTN3 R577X genotype influence muscle power, strength, and fatigability in moderately to well-trained individuals?
The ACTN3 R577X polymorphism is not associated with baseline differences in power output or fatigability in moderately trained individuals, but may modulate responsiveness to training and affect ACTN2 expression.
Norman et al. (2009) conducted a cross-sectional in Healthy moderately to well-trained individuals (n=120). ACTN3 R577X genotype vs. Other ACTN3 genotypes was evaluated on Peak and mean power, torque-velocity relationship, and fatigability output. The ACTN3 R577X polymorphism was not associated with differences in power output, fatigability, or force-velocity characteristics in moderately trained individuals.
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