Evolving importance of kidney disease: from subspecialty to global health burden
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Discussion
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Implication
Review reveals high global prevalence and systemic impacts of chronic kidney disease in general populations, highlighting the need for collaborative clinical management.
Key Points
- Synthesize evidence on the expanding global epidemiological burden, prognostic hallmarks, and systemic pathophysiological consequences of acute and chronic kidney disease.
- Narrative synthesis of population-level prevalence and clinical outcome studies evaluating kidney disease.
- Evaluation of objective functional biomarkers, specifically glomerular filtration rate and urinary albumin excretion, across demographic subgroups.
- Chronic kidney disease prevalence exceeds 10% in general populations and surpasses 50% in high-risk subpopulations.
- Reduced glomerular filtration rate and elevated urinary albumin excretion exhibit strong, graded, and consistent associations with adverse clinical prognosis independent of age, sex, ethnicity, and comorbidities.
- Acute declines in glomerular filtration rate heighten the risk of chronic kidney disease progression and provoke widespread systemic disease by disrupting homeostatic pathways.
Cite This Study
Eckardt et al. (2013) studied this question.