Key result
Renin-containing cells were localized in the medulla oblongata, cerebellar nuclei, hypothalamus, pineal gland, adenohypophysis, and choroid plexus of rat and mouse brains.
Population
Rat and mouse brain
Design
Preclinical
Authors
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Supports brain renin mapping in rodents; leaves open its relevance to human cardiovascular regulation.
The extensive distribution of renin in rat and mouse brains suggests it has functions beyond those associated with the hypothalamus.
Inagami et al. (1980) studied this question. Immunohistochemical identification of renin was evaluated on Localization of renin in rat and mouse brain. Renin-containing cells were localized in the medulla oblongata, cerebellar nuclei, hypothalamus, pineal gland, adenohypophysis, and choroid plexus of rat and mouse brains.
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