Pharmacological Profile of Loop Diuretic in Experimental Model of Heart Failure

Loop diuretics such as furosemide are first-line drugs for patients with decompensated heart failure (HF). The study aims to describe the implementation and standardization of an experimental model in diuresis at the Laboratory of Research and Graduate Studies in Pharmacology at the Federal University of Maranho. Rats were randomly divided: furosemide (furosemide) group received 10 mg/kg furosemide, without CI; The Heart Failure Group (Vehicle-HF) received 10ml/kg of water and the Heart Failure-Furosemide Group (Furosemide-HF) received 10mg/kg of furosemide. IC was induced by isoproterenol for seven days. Oral treatment took place for 7 days to assess food and water intake, weight gain, urinary volume, excretion and diuretic activity. The rodents with HF showed cardiac hypertrophy and body weight loss in the induction process.