Key result
MASLD severity does not correlate with TIMI coronary blood flow in catheterization patients.
Why the study?
Metabolic dysfunction-associated steatotic liver disease represents a state of chronic inflammation that may coexist with carotid or coronary atheromatous disease, and previous studies have demonstrated a possible association between fatty liver and carotid artery disease.
Does the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) correlate with impaired coronary artery flow (TIMI grade) in hospitalized patients undergoing cardiac catheterization?
Cross-Sectional (n=42)
No
Does the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) correlate with impaired coronary artery flow (TIMI grade) in hospitalized patients undergoing cardiac catheterization?
In this small cross-sectional study of 42 patients undergoing non-urgent cardiac catheterization, the severity of hepatic steatosis (MASLD) assessed by ultrasound did not correlate with coronary artery blood flow (TIMI grade) or coronary artery disease extension.
No correlation between MASLD severity and TIMI flow in this cross-sectional cohort; leaves open any link in prospective studies.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the hepatic manifestation of metabolic syndrome, representing a state of chronic inflammation.It may coexist with atheromatous disease in carotid or coronary arteries.Previous studies have demonstrated a possible association between the presence of fatty liver and the development of carotid artery disease.(1,2) Material and Methods: A descriptive, observational, cross-sectional, and analytical study was conducted.All adult patients undergoing cardiac catheterization who did not present an acute coronary syndrome were included.Abdominal ultrasound was performed to assess hepatic status.Both procedure reports were analyzed and recorded on a data collection sheet for subsequent statistical evaluation.Results: In the correlation analysis between the degree of metabolic dysfunction-associated steatotic liver disease (MASLD) and the degree of coronary flow assessed by the TIMI classification, no statistically significant relationship was found.Kendall's Tau_b test showed a coefficient of -0.094 with a p value of 0.518, indicating the absence of correlation between both variables.Conclusion: These findings suggest that, in the studied population, the severity of fatty liver determined by liver ultrasound is not associated with the degree of alteration in coronary flow measured by coronary angiography.It is recommended to expand this research using more robust quantitative variables, such as hepatic elastography and the percentage of arterial occlusion, to obtain more precise information about the relationship between hepatic and coronary disease.
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Olavide-Aguilar et al. (2026) conducted a cross-sectional in Metabolic dysfunction-associated steatotic liver disease (MASLD) and coronary artery disease (n=42). Metabolic dysfunction-associated steatotic liver disease (MASLD) severity assessed by liver ultrasound vs. Absence of hepatic steatosis (Grade 0 MASLD) was evaluated on Correlation between degree of MASLD and degree of coronary artery flow assessed by TIMI classification (Kendall's tau -0.094, p=0.518). MASLD severity assessed by liver ultrasound was not significantly correlated with TIMI coronary artery blood flow grade in hospitalized catheterization patients (Kendall's tau -0.094, p=0.518).
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