Key result
A single injection of doxorubicin in rats led to an initial decrease in cytoskeletal proteins, followed at 3 weeks by diffuse fibrosis and increased tubulin and KRP expression.
Why the study?
Does a single injection of doxorubicin alter myocardial cytoskeletal and regulatory protein expression in rat hearts and chick embryo cardiomyocytes?
Population
Rat heart model and isolated chick embryo cardiomyocytes
Comparison
Single injection of doxorubicin vs Untreated animals/cells
Design
Preclinical
Follow-up
Up to 3 weeks (rats) and 4 days (chick embryos)
Authors
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Doxorubicin induces rat myocardial ECM remodeling and fibrosis; leaves open human cardiotoxicity mechanisms and prevention targets.
Does a single injection of doxorubicin alter myocardial cytoskeletal and regulatory protein expression in rat hearts and chick embryo cardiomyocytes?
A single dose of doxorubicin induces acute and delayed alterations in myocardial cytoskeletal and extracellular matrix proteins, suggesting a compensatory reparative response to myocardial damage.
Dudnakova et al. (2003) studied Doxorubicin-induced myocardial alterations. Doxorubicin vs. Untreated animals / control level was evaluated on Expression levels of cytoskeletal and extracellular matrix proteins and collagen network structure. A single injection of doxorubicin in rats led to an initial decrease in cytoskeletal proteins, followed at 3 weeks by diffuse fibrosis and increased tubulin and KRP expression.
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