Key result
Exposure of isolated cardiomyocytes to reactive oxygen species (H2O2 or superoxide anion) triggered apoptosis through distinct signaling pathways involving p53, Bax/Bad, and Mch2alpha.
Why the study?
Do different reactive oxygen species trigger apoptosis in cardiomyocytes through distinct signaling pathways?
Population
Isolated cardiac cells (cell culture model)
Design
Preclinical
Authors
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ROS may promote cardiomyocyte loss in vitro; leaves open relevance to human heart disease.
Do different reactive oxygen species trigger apoptosis in cardiomyocytes through distinct signaling pathways?
Different reactive oxygen species (H2O2 vs O2-) induce cardiomyocyte apoptosis through distinct signaling pathways, highlighting the complex pathophysiological role of ROS in cardiac diseases.
Harsdorf et al. (1999) studied Cardiomyocyte Apoptosis. Reactive oxygen species (H2O2 or superoxide anion) was evaluated on Apoptosis and underlying signaling pathways. Exposure of isolated cardiomyocytes to reactive oxygen species (H2O2 or superoxide anion) triggered apoptosis through distinct signaling pathways involving p53, Bax/Bad, and Mch2alpha.
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