January 1, 2002Circulation JournalOpen Access

Serum Hepatocyte Growth Factor Predicts Ventricular Remodeling Following Myocardial Infarction.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute Myocardial Infarction (n=80). Intervention: Serum Hepatocyte Growth Factor (HGF) concentration vs. Nonremodeling group. Primary outcome: Serum HGF concentration on day 7 in patients with vs without left ventricular remodeling (p=0.003).

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Key result

Serum hepatocyte growth factor concentration on day 7 after acute myocardial infarction was significantly higher in patients who subsequently developed left ventricular remodeling compared to those who did not (0.47 vs 0.36 ng/ml).

Why the study?

Does serum HGF or VEGF concentration predict left ventricular remodeling following acute myocardial infarction?

Study Design

Type

Observational (n=80)

Blinding

Single-blind

Multicenter

Structured PICO

Does serum HGF or VEGF concentration predict left ventricular remodeling following acute myocardial infarction?

Population

80 participants, comprising 40 patients with a first anterior acute myocardial infarction treated with successful angioplasty and 40 matched controls, followed for 3 months to assess left ventricular remodeling.

Exposure

Measurement of serum hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) concentrations at admission, and on days 7, 14, and 21.

Comparator

Control subjects (for baseline biomarker comparison) and non-remodeling AMI patients (for prognostic comparison).

Outcome

Left ventricular remodeling, defined as an increase in left ventricular end-diastolic volume index >= 5 ml/m2 in the chronic phase (3 months) relative to the baseline value in the subacute phase (1 week) assessed by left ventriculography.surrogate

Main Result

Absolute Event Rate: 0.47% vs 0.36%

p-value: p=0.003

Limitations

All patients with AMI underwent successful percutaneous transluminal coronary angioplasty; changes in patients without angioplasty were not evaluated.
Concentrations of HGF and VEGF were compared at only 2 sites (coronary sinus and peripheral vein), leaving the main sources uncertain.
The remodeling group was defined by an increase in left ventricular end-diastolic volume index relative to the subacute phase (1 week) rather than the acute phase.
All patients with AMI underwent successful percutaneous transluminal coronary angioplasty; changes in serum HGF or VEGF were not evaluated in patients who did not undergo angioplasty.
Concentrations of HGF and VEGF were compared at only 2 sites (coronary sinus and peripheral vein), so the main sources remain uncertain.
The remodeling group was defined by an increase in left ventricular end-diastolic volume index in the chronic phase relative to the subacute phase (1 week), not the acute phase (day 1).

Discussion

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Implication

Elevated serum HGF concentrations on day 7 following acute myocardial infarction predict subsequent left ventricular remodeling, suggesting a role in the post-infarction inflammatory and healing process.

Cite This Study

Soeki et al. (2002) conducted an observational in Acute Myocardial Infarction (n=80). Serum Hepatocyte Growth Factor (HGF) concentration vs. Nonremodeling group was evaluated on Serum HGF concentration on day 7 in patients with vs without left ventricular remodeling (p=0.003). Serum hepatocyte growth factor concentration on day 7 after acute myocardial infarction was significantly higher in patients who subsequently developed left ventricular remodeling compared to those who did not (0.47 vs 0.36 ng/ml).

synapsesocial.com/papers/6a6bce4b47a1bfb288f3490e https://doi.org/10.1253/circj.66.1003

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Serum Hepatocyte Growth Factor Predicts Ventricular Remodeling Following Myocardial Infarction.

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Serum Hepatocyte Growth Factor Predicts Ventricular Remodeling Following Myocardial Infarction.

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider