Key result
Kv7 channel subtypes are expressed in guinea pig detrusor smooth muscle cells, and their pharmacological activation with retigabine or L-364373 significantly inhibits spontaneous and nerve-evoked contractions.
Kv7 channel subtypes are expressed in guinea pig detrusor smooth muscle and their pharmacological modulation controls contractility, suggesting they are potential therapeutic targets for urinary bladder dysfunction.
No takes yet. Share an insight, caveat, or question.
Kv7 expression in DSM is hypothesis-generating; leaves open functional roles and therapeutic targeting in human bladder disorders.
Afeli et al. (2013) studied Normal detrusor smooth muscle function (animal model) (n=49). Kv7 channel modulators (L-364373, retigabine, XE991, linopiridine) vs. Control (pre-drug baseline) was evaluated on Spontaneous phasic and EFS-induced contractions. Kv7 channel subtypes are expressed in guinea pig detrusor smooth muscle cells, and their pharmacological activation with retigabine or L-364373 significantly inhibits spontaneous and nerve-evoked contractions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: