Key result
The neuronal specific BKbeta4 subunit was identified alongside BKalpha and BKbeta1 in freshly isolated mouse and rat bladder smooth muscle cells.
The study identifies the expression of the BKbeta4 subunit in mouse and rat bladder smooth muscle, suggesting a distinctive architecture of the BK channel that could be a target for overactive bladder therapies.
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May inform BK-targeted overactive bladder therapies; leaves open functional role and human relevance.
Chen et al. (2009) studied this question. BKbeta4 subunit expression analysis was evaluated on Expression of BKbeta4 subunit. The neuronal specific BKbeta4 subunit was identified alongside BKalpha and BKbeta1 in freshly isolated mouse and rat bladder smooth muscle cells.
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