June 8, 2004Journal of Biological ChemistryOpen Access

Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel

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Why the study?

Does the deletion of the mSlo1 gene (BK channel) affect urinary bladder contractility and urination frequency in mice?

Population

Slo(-/-) mice with deleted mSlo1 gene for the pore-forming subunit of the BK channel

Design

Preclinical

Authors

AMAndrea L. MeredithUniversity of Mary KTKevin S. ThorneloeBJC HealthCare MWMatthias WernerUniversität der Bundeswehr München

Discussion

Member takes

Implication

BK channels suppress murine bladder contractility; leaves open whether activation could treat human overactive bladder.

Structured PICO

Does the deletion of the mSlo1 gene (BK channel) affect urinary bladder contractility and urination frequency in mice?

Population

Slo(-/-) mice with deleted mSlo1 gene for the pore-forming subunit of the BK channel

Intervention

Deletion of the mSlo1 gene (absence of BK channels)

Outcome

Urinary bladder smooth muscle function, contractility, and urination frequencysurrogate

Deletion of the BK channel in mice leads to enhanced bladder contractility and increased urination frequency, suggesting BK channels are potential targets for overactive bladder therapy.

Cite This Study

Meredith et al. (2004) studied this question.

synapsesocial.com/papers/6a8040a37a38d5ff71e4553c https://doi.org/10.1074/jbc.m405621200

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Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider