Population
Gene-targeted mice for the beta1-subunit gene (beta1-subunit-knockout allele)
Comparison
Knockout of the beta1-subunit gene vs Wild-type mice (implied)
Design
Preclinical
Authors
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Animal data link BK beta1-subunit loss to enhanced tracheal constriction; hypothesis-generating for airway therapies pending human studies.
The BK channel beta1-subunit is required in airway smooth muscle to control voltage-dependent Ca2+ influx and regulate tracheal constriction.
Semenov et al. (2006) studied this question.
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