Key result
Concurrent recording of muscle sympathetic nerve activity and fMRI in awake subjects revealed that increases in MSNA were associated with robust bilateral increases in BOLD signal in the RVLM.
Population
Awake human subjects
Authors
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May advance brainstem mapping of sympathetic control; hypothesis-generating and requires validation before any clinical application.
Observational
Combined recording of sympathetic neural activity and fMRI provides real-time imaging of the neural processes responsible for generating sympathetic nerve activity in awake humans.
Macefield et al. (2009) reported an observational. Concurrent muscle sympathetic nerve activity (MSNA) recording and fMRI was evaluated on Temporal coupling between BOLD signal intensity and nerve signal intensity in the medulla. Concurrent recording of muscle sympathetic nerve activity and fMRI in awake subjects revealed that increases in MSNA were associated with robust bilateral increases in BOLD signal in the RVLM.
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