Key result
Ultrasound and microbubbles enhance thrombolysis in stroke models, but require further optimization before clinical translation.
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Improved treatment of acute ischemic stroke with ultrasound and microbubbles in combination with thrombolytic drugs shows great promise, but the optimal techniques, indications, and contraindications have not yet been well defined. Moreover, details such as microbubble dosage, delivery, required thrombolytic drug dosage, and optimal ultrasound characteristics all remain uncertain. Recent results suggest that ultrasound and microbubbles may be effective in clot lysis of ischemic stroke without additional thrombolytic drugs. Moreover, targeting thrombus with specific immunobubbles may improve the efficacy of sonothrombolysis. Safety remains a major concern in the further development of ultrasound-enhanced thrombolysis and extensive animal work is required to define the most promising methods to translate into human application.
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Meairs et al. (2009) conducted a review in Acute ischemic stroke. Ultrasound and microbubbles in combination with thrombolytic drugs was evaluated. Ultrasound and microbubbles show promise in enhancing thrombolysis for acute ischemic stroke, though further animal work is needed to define optimal techniques and ensure safety for human translation.
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