What question did this study set out to answer?

This study aims to determine how magnetic resonance imaging can predict responses to thrombolytic therapy in patients with deep vein thrombosis.

January 1, 1995Thrombosis and Haemostasis

Magnetic Resonance Imaging of Deep Vein Thrombi Correlates with Response to Thrombolytic Therapy

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Key result

The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data.

Why the study?

Does magnetic resonance imaging predict the response of deep vein thrombi to thrombolytic therapy in patients with proximal DVT?

Population

9 patients with venographically documented proximal deep vein thrombosis, comprising 55 vein segments with…

Design

Cohort

Authors

CFCharles W. FrancisVascular Medicine STSaara TöttermanUniversity of Turku

Discussion

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Implication

MR thrombus features may identify DVT patients likely to respond to fibrinolysis; leaves open whether imaging can guide therapy selection.

Key Points

This study aims to determine how magnetic resonance imaging can predict responses to thrombolytic therapy in patients with deep vein thrombosis.
Nine patients with venographically documented DVT treated with streptokinase were examined.
MR imaging using a gradient recall echo sequence was performed before and after therapy.
The thrombus was assessed by comparing MR images to determine clot lysis.
MR imaging accurately identified thrombus in all cases compared to venography (p < .001).
Clot lysis occurred in 53% of segments with a uniform low signal intensity versus 5% with high or intermediate intensity (p < .001).
Low MR signal intensity correlated with shorter symptom duration of four days or less and partial vein occlusion.

Structured PICO

Does magnetic resonance imaging predict the response of deep vein thrombi to thrombolytic therapy in patients with proximal DVT?

Population

9 patients with venographically documented proximal deep vein thrombosis (DVT), comprising 55 vein segments with thrombus

Intervention

Streptokinase therapy with magnetic resonance (MR) imaging using a gradient recall echo sequence performed before and after therapy

Outcome

Amount of clot lysis determined by comparing pre- and post-treatment MR imagessurrogate

Low MR signal intensity of deep vein thrombi correlates with shorter symptom duration and incomplete vein obstruction, and significantly predicts successful clot lysis following thrombolytic therapy.

Cite This Study

Francis et al. (1995) studied this question. The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data.

synapsesocial.com/papers/6a6be75b050bc01bbbcb8b32 https://doi.org/10.1055/s-0038-1653785

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Implication

MR thrombus features may identify DVT patients likely to respond to fibrinolysis; leaves open whether imaging can guide therapy selection.

Magnetic Resonance Imaging of Deep Vein Thrombi Correlates with Response to Thrombolytic Therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Magnetic Resonance Imaging of Deep Vein Thrombi Correlates with Response to Thrombolytic Therapy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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