Association Between Lactate/Albumin Ratio and Mortality in Patients with Heart Failure After Myocardial Infarction

Figures

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  Figure 1. Schematic diagram of the study sample selection steps. The Medical Information Mart for Intensive Care IV (MIMIC‐IV) (version 1.0) database includes relatively comprehensive medical information on 382 278 patients, 523 740 admissions, and 76 540 intensive care unit (ICU) admissions. In total, 6644 admitted patients were diagnosed with myocardial infarction and heart failure. The sample of patients meeting the exclusion criteria in the figure was excluded (n = 4018). Ultimately, 2626 patients were included in this study, of whom 305 died. HF, heart failure; MI, myocardial infarction.

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  Figure 2. Receiver operating characteristic (ROC) curves for predictors related to in‐hospital mortality index. The solid blue line indicates the ROC curve for admission L/A, and the AUC was better for admission L/A and Sequential Organ Failure Assessment (SOFA). DeLong's test showed that the AUC was better in the admission L/A group than in the admission SOFA group [0.800 (95% CI: 0.772–0.828) vs 0.753 (95% CI: 0.721–0.785), P < 0.05]. AUC, area under the curve; CI, confidence interval; L/A, lactate/albumin ratio; SIRS, Systemic Inflammatory Response Syndrome score.

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  Figure 3. Relationship between admission lactate/albumin ratio (L/A) and in‐hospital mortality risk. Hazard ratio (HR) is indicated by the blue solid line and 95% confidence interval (CI) is indicated by the blue dashed line. In multivariate Cox analysis, the model was adjusted for cofounders with P values <0.05. SIRS, Systemic Inflammatory Response Syndrome score.

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  Figure 4. Kaplan–Meier curve were applied for samples with different admission lactate/albumin ratio (L/A) levels. The survival probability of samples in high admission L/A group (L/A ≥ 0.671) is indicated by solid red line, while samples in low admission L/A group (L/A < 0.671) are indicated by solid blue line. The survival curve of high admission rate L/A group was significantly lower than that of low admission rate L/A group (log rank test: P < 0.001).