Lactate is a Prognostic Factor in Patients Admitted With Suspected ST-Elevation Myocardial Infarction
Key result
Admission lactate concentration was independently associated with 30-day mortality in patients with suspected STEMI (HR 1.11; 95% CI 1.07-1.14; P < 0.0001).
Why the study?
Does admission lactate concentration predict 30-day mortality in patients admitted with suspected STEMI?
Population
2,094 consecutive subjects admitted with suspected ST-elevation myocardial infarction (STEMI)
Design
Cohort
Follow-up
30-day
Authors
Discussion
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Member takes
Implication
May support lactate assessment in suspected STEMI; leaves open whether routine use improves outcomes.
Study Design
Type
Cohort (n=2,094)
Structured PICO
Does admission lactate concentration predict 30-day mortality in patients admitted with suspected STEMI?
P
Population
2,094 consecutive subjects admitted with suspected STEMI, assessed for 30-day mortality.
E
Exposure
Admission lactate concentration measurement
O
Outcome
30-day mortalityhard clinical
Main Result
Hazard Ratio: 1.11 (95% CI 1.07–1.14)
p-value: p=< 0.0001
Admission lactate concentration provides independent prognostic information for 30-day mortality in suspected STEMI patients, improving risk stratification beyond standard clinical and hemodynamic variables.
Cite This Study
Frydland et al. (2018) conducted a cohort in Suspected ST-elevation myocardial infarction (STEMI) (n=2,094). Admission lactate concentration was evaluated on 30-day mortality (HR 1.11, 95% CI 1.07-1.14, p=< 0.0001). Admission lactate concentration was independently associated with 30-day mortality in patients with suspected STEMI (HR 1.11; 95% CI 1.07-1.14; P < 0.0001).