What question did this study set out to answer?

The aim is to characterize a fucosylated chondroitin sulfate from sea cucumbers and assess its anticoagulant properties.

Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm

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Randomized trial evaluates anticoagulant effects of fucosylated chondroitin sulfate in sea cucumber, indicating distinct therapeutic potential.

The aim is to characterize a fucosylated chondroitin sulfate from sea cucumbers and assess its anticoagulant properties.
Isolated polysaccharide from Ludwigothurea grisea body wall.
Characterized using mild acid hydrolysis and 1H NMR spectroscopy.
Conducted thrombin inhibition assays with purified reagents.
Fucosylated chondroitin sulfate shows increased anticoagulant activity compared to linear alpha-L-fucan in the activated partial thromboplastin time assay (specific activity greater than linear fucan).
Anticoagulant activity is lost upon defucosylation or desulfation but preserved after carboxyl-reduction.
The fucosylated chondroitin sulfate enhances thrombin inhibition of antithrombin and heparin cofactor II.

Mourão et al. (1996) studied this question.

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Randomized trial evaluates anticoagulant effects of fucosylated chondroitin sulfate in sea cucumber, indicating distinct therapeutic potential.