Key result
A 3-month aerobic exercise intervention in older sedentary men alleviated age-related increases in endothelin-1-mediated vasoconstrictor tone, increasing the response to endothelin-1 by 225% (P<0.05).
Why the study?
Does regular aerobic exercise reduce endothelin-1-mediated vasoconstrictor tone in healthy older men?
Population
28 healthy, sedentary men (13 younger, age 27+/-1 years; 15 older, age 62+/-2 years)
Comparison
3-month aerobic exercise intervention vs Younger men and pre-intervention baseline
Design
Cohort
Follow-up
3 months
Authors
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May support aerobic exercise to offset age-related endothelin-1 tone in men; leaves open links to hypertension outcomes.
Does regular aerobic exercise reduce endothelin-1-mediated vasoconstrictor tone in healthy older men?
p-value: p=<0.05
Endothelin-1-mediated vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise.
Guilder et al. (2007) studied Healthy, sedentary (n=28). Aerobic exercise vs. Sedentary baseline was evaluated on Vasoconstrictor response to endothelin-1 (p=<0.05). A 3-month aerobic exercise intervention in older sedentary men alleviated age-related increases in endothelin-1-mediated vasoconstrictor tone, increasing the response to endothelin-1 by 225% (P<0.05).
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