No pigs, no cows needed: Chondroitin sulfate for pharmacological uses is obtained from animal sources in low abundance and with a laborious downstream purification. It has now been synthesized for the first time by an innovative microbiological–chemical approach consisting of chondroitin production from E. coli K4 fed-batch fermentation and its subsequent regioselective sulfation in five steps and 61 % overall yield (see scheme).
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Bedini et al. (2011) studied this question.
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