Key result
Rat brain and lung ACE isozymes differ in molecular weight and their ability to cleave amidated peptides like substance P and substance K, suggesting a specific physiological role in the brain.
Population
Rat brain corpus striatum and rat lung tissue
Comparison
Purification and biochemical characterization of… vs Comparison between brain ACE and lung ACE
Design
Preclinical
Authors
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Hypothesis-generating for brain-specific ACE roles; leaves open human translation and clinical relevance.
Rat brain ACE is a distinct isozyme from lung ACE, possessing unique specificity for amidated peptide substrates like substance P and substance K.
Strittmatter et al. (1985) studied this question. Rat brain and lung angiotensin-converting enzyme (ACE) was evaluated on Enzyme characteristics and cleavage of amidated peptides. Rat brain and lung ACE isozymes differ in molecular weight and their ability to cleave amidated peptides like substance P and substance K, suggesting a specific physiological role in the brain.
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