Key result
In Dictyostelium discoideum membranes, adenylate cyclase is regulated by Gs-like and Gi-like activities, with Gs action lost during in vivo desensitization and in vitro phosphorylation.
Population
Dictyostelium discoideum membranes (wild-type and mutant N7 cells)
Comparison
Guanine nucleotides, cAMP, pertussis toxin, and… vs Control conditions
Design
Preclinical
Authors
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Supports dual G-protein regulation of adenylate cyclase in a model system; leaves open relevance to mammalian cardiac signaling.
Dictyostelium discoideum adenylate cyclase appears to be regulated by both Gs-like and Gi-like activities, with Gs action lost during desensitization and phosphorylation.
Haastert et al. (1987) studied this question. Guanine nucleotides was evaluated on Adenylate cyclase activity. In Dictyostelium discoideum membranes, adenylate cyclase is regulated by Gs-like and Gi-like activities, with Gs action lost during in vivo desensitization and in vitro phosphorylation.
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