What question did this study set out to answer?

The aim is to study the stability of progestogens in human colonic microbiota to improve drug delivery methods.

August 12, 2020PharmaceuticsOpen Access

Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery

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Randomized trial investigates colonic drug delivery of progestogens, suggesting potential pharmacokinetic benefits.

The aim is to study the stability of progestogens in human colonic microbiota to improve drug delivery methods.
Progestogens (progesterone, MPA, LNG) incubated in mixed fecal inoculum under anaerobic conditions.
Stability measured by the detectable levels of hormones over time.
Half-lives of progestogens in fecal inoculum determined.
Progesterone completely degraded after 2 h; MPA and LNG detectable after 24 h.
Half-lives: progesterone 28 min, MPA 644 min, LNG 240 min.
MPA and LNG show potential for better colonic delivery compared to current oral methods.

Coombes et al. (2020) studied this question.

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