Key result
Increasing coronary aneurysm size in Kawasaki disease significantly decreased the average peak velocity index (from 0.893 in small to 0.128 in large aneurysms; p<0.005) and shear index.
Why the study?
Does aneurysm size affect coronary flow velocity, perfusion pressure, and shear stress in patients with Kawasaki disease?
Population
33 patients with Kawasaki disease and 43 coronary aneurysms, mean age 6.1 +/- 4.3 years.
Comparison
Hemodynamic assessment using Doppler flow… vs Adjacent normal-looking vessels.
Design
Cross-sectional
Authors
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Larger aneurysms linked to flow stagnation may elevate thrombosis risk in Kawasaki disease; hypothesis-generating for shear-mediated mechanisms.
Observational (n=33)
Does aneurysm size affect coronary flow velocity, perfusion pressure, and shear stress in patients with Kawasaki disease?
p-value: p=< 0.005
In patients with Kawasaki disease, larger coronary aneurysms exhibit significant flow stagnation and reduced shear stress, which may predispose to thrombus formation.
Kuramochi et al. (2000) conducted an observational in Kawasaki disease (n=33). Coronary aneurysm size vs. Adjacent normal-looking vessels was evaluated on Average peak velocity (APV) index and shear index (p=< 0.005). Increasing coronary aneurysm size in Kawasaki disease significantly decreased the average peak velocity index (from 0.893 in small to 0.128 in large aneurysms; p<0.005) and shear index.
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