Key result
Acetazolamide at 10 microM inhibited the relative invasion rate of four renal carcinoma cell lines by 18-74% in vitro.
Why the study?
Does acetazolamide reduce the invasive capacity of renal carcinoma cell lines in vitro?
Does acetazolamide reduce the invasive capacity of renal carcinoma cell lines in vitro?
Effect estimate: 18-74% inhibition
Acetazolamide reduces the invasiveness of renal cancer cells in vitro, suggesting a potential role for carbonic anhydrase inhibitors in targeting tumor invasion.
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In vitro acetazolamide effects on renal carcinoma invasion are hypothesis-generating; should not change practice pending in vivo data.
Parkkila et al. (2000) studied Renal cancer. Acetazolamide was evaluated on Relative invasion rate (18-74% inhibition). Acetazolamide at 10 microM inhibited the relative invasion rate of four renal carcinoma cell lines by 18-74% in vitro.
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