Comparison of Insulin Regimens in Patients with Non-Insulin-Dependent Diabetes Mellitus
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Discussion
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Implication
Randomized trial compares insulin regimens' effectiveness in non-insulin-dependent diabetes mellitus, suggesting fewer injections may be better.
Key Points
- This research aims to evaluate the effectiveness of different insulin regimens in patients with non-insulin-dependent diabetes mellitus (NIDDM).
- 153 patients with NIDDM treated for three months with five insulin regimens.
- Regimens included morning-NPH, evening-NPH, two-insulin-injections, multiple-insulin-injections, and control group with oral hypoglycemic therapy.
- Glycosylated hemoglobin, weight gain, and serum insulin concentrations were measured.
- Glycosylated hemoglobin decreased in all four insulin regimens compared to control (P < 0.001).
- Evening-NPH group gained significantly less weight (1.2 kg) than other groups (P < 0.05).
- Subjective well-being improved in insulin treatment groups versus control (P < 0.001).
Cite This Study
Yki‐Järvinen et al. (1992) studied this question.