Key result
As sarcomere length decreases from 2.80 to 1.58 microns in rat hindlimb muscles, the capillary-to-fiber perimeter ratio changes by 10-15% or less.
Population
perfusion-fixed hindlimb muscles of rats
Design
Preclinical
Authors
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Minimal sarcomere length effects on rat muscle capillary geometry suggest structural stability; leaves open translation to human cardiac microvasculature.
The capillary-to-fiber perimeter ratio is a robust morphometric measure that changes relatively little with variations in sarcomere length during muscle shortening or extension.
Mathieu‐Costello et al. (1991) studied Muscle morphometry. Sarcomere length variation was evaluated on Capillary-to-fiber perimeter ratio. As sarcomere length decreases from 2.80 to 1.58 microns in rat hindlimb muscles, the capillary-to-fiber perimeter ratio changes by 10-15% or less.
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