Key result
Non-traumatic and non-drug-induced rhabdomyolysis is a rare, potentially life-threatening condition caused by genetic disorders, endocrine abnormalities, infections, and muscle ischemia.
This review provides a comprehensive overview of the diverse genetic and acquired etiologies of non-traumatic, non-drug-induced rhabdomyolysis to aid in clinical recognition and management.
Raises clinician awareness of non-traumatic rhabdomyolysis complexity; leaves open prospective validation of targeted management.
Rhabdomyolysis (RM), a fortunately rare disease of the striated muscle cells, is a complication of non-traumatic (congenital (glycogen storage disease, discrete mitochondrial myopathies and various muscular dystrophies) or acquired (alcoholic myopathy, systemic diseases, arterial occlusion, viral illness or bacterial sepsis)) and traumatic conditions. Additionally, RM can occur in some individuals under specific circumstances such as toxic substance use and illicit drug abuse. Lipid-lowering drugs in particular are capable of causing RM. This comprehensive review will focus on non-traumatic and non-drug-induced RM. Moreover, the pathology of RM, its clinical manifestation and biochemical effects, and finally its management will be discussed.
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Kolovou et al. (2019) conducted a review in Non-traumatic and non-drug-induced rhabdomyolysis. Non-traumatic and non-drug-induced rhabdomyolysis is a rare, potentially life-threatening condition caused by genetic disorders, endocrine abnormalities, infections, and muscle ischemia.
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