Key result
The nonlinear correlation index D* showed a stronger monotonic relationship with the estimated depth of Sevoflurane anesthesia (median rank correlation -0.90) compared to the bispectral index (median -0.82, p<0.05).
Why the study?
Does the nonlinear correlation index D* better indicate depth of anesthesia compared to established spectral measures in patients anesthetized with sevoflurane?
Population
17 patients anesthetized with sevoflurane
Comparison
Nonlinear correlation index D* computed from… vs Three established EEG measures
Authors
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D* may better track sevoflurane depth than BIS; this Level 5 finding leaves open prospective validation before any practice change.
Observational (n=17)
Does the nonlinear correlation index D* better indicate depth of anesthesia compared to established spectral measures in patients anesthetized with sevoflurane?
Absolute Event Rate: -0.9% vs -0.82%
p-value: p=<0.05
A phase space-based nonlinear correlation index (D*) of EEG signals may provide a more reliable indicator of anesthesia depth than traditional spectral measures.
Widman et al. (2000) conducted an observational in Patients undergoing elective surgery requiring anesthesia (n=17). Nonlinear correlation index D* (EEG measure) vs. Bispectral index (bis) and spectral measures (fmedian, fse95) was evaluated on Spearman's rank correlation coefficient (ρ) between estimated effective brain concentration of Sevoflurane and EEG measure (p=<0.05). The nonlinear correlation index D* showed a stronger monotonic relationship with the estimated depth of Sevoflurane anesthesia (median rank correlation -0.90) compared to the bispectral index (median -0.82, p<0.05).
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