Key result
Intravascular adenosine triphosphate (ATP) may act as a primary factor in regulating vascular tone, and deficient ATP release could contribute to impaired vascular control in aged and diseased populations.
Why the study?
What is the role of intravascular ATP in the regulation of blood flow and oxygen delivery in humans?
What is the role of intravascular ATP in the regulation of blood flow and oxygen delivery in humans?
Highlights the potential role of intravascular ATP in vascular control and hypothesizes its deficiency as a mechanism for impaired regulation in high-risk populations.
ATP deficiency may impair vascular control in high-risk groups; hypothesis-generating and requires prospective trials before clinical consideration.
In Brief Regulation of vascular tone is a complex response that integrates multiple signals that allow for blood flow and oxygen supply to match oxygen demand appropriately. Here, we discuss the potential role of intravascular adenosine triphosphate (ATP) as a primary factor in these responses and put forth the hypothesis that deficient ATP release contributes to impairments in vascular control exhibited in aged and diseased populations. Adenosine triphosphate is involved in vascular control during exercise and hypoxia and may explain impaired regulation in certain high-risk populations.
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Crecelius et al. (2014) conducted a review in Impaired vascular control. Intravascular adenosine triphosphate (ATP) was evaluated. Intravascular adenosine triphosphate (ATP) may act as a primary factor in regulating vascular tone, and deficient ATP release could contribute to impaired vascular control in aged and diseased populations.
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