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March 10, 2011ScienceOpen Access

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

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WTWei TangShandong UniversityYLYi LuShandong UniversityQTQingyun TianMinistry of Education of the People's Republic of China

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Tang et al. (2011) studied this question.

synapsesocial.com/papers/6a6c15fa01245da06ecbb1cfhttps://doi.org/10.1126/science.1199214
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TNF downmodulates the function of human CD4+CD25hi T-regulatory cells2006 · 780 citations
  2. 2Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis2010 · 124 citations
  3. 3Structure dissection of human progranulin identifies well‐folded granulin/epithelin modules with unique functional activities2008 · 164 citations