Key result
Anode break stimulation in single ventricular cells is driven by the recruitment of the hyperpolarization-activated inward current I(f) and time-dependent block of the inward rectifier I(K1).
Active cellular properties, specifically the hyperpolarization-activated inward current I(f) and I(K1) block, are sufficient to explain anode break stimulation in single cardiac cells.
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May indicate cellular basis for anodal stimulation; leaves open revision of single-cell models for tissue predictions.
Ranjan et al. (1998) studied Cardiac electrophysiology. Anodal stimulation was evaluated on Membrane potential and membrane current. Anode break stimulation in single ventricular cells is driven by the recruitment of the hyperpolarization-activated inward current I(f) and time-dependent block of the inward rectifier I(K1).
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