Key result
Extracellular electrical shocks applied to cultured cell strands revealed that small intercellular clefts can create secondary sources of sufficient magnitude to exert a stimulatory effect.
Population
Cultured monolayers and patterned strands of neonatal rat ventricular myocytes
Design
Preclinical
Authors
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May influence shock responses in myocyte cultures; leaves open relevance to clinical defibrillation efficacy.
This preclinical study demonstrates that microscopic tissue discontinuities, such as intercellular clefts, act as secondary electrical sources during extracellular shocks, providing mechanistic insights into cardiac defibrillation and arrhythmogenesis.
Gillis et al. (1996) studied Cultured monolayers of neonatal rat ventricular myocytes. Extracellular electrical shocks (EESs) was evaluated on Spatial distribution of the transmembrane potential (delta Vm/APA) and occurrence of secondary sources. Extracellular electrical shocks applied to cultured cell strands revealed that small intercellular clefts can create secondary sources of sufficient magnitude to exert a stimulatory effect.
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