Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 1993Circulation ResearchOpen Access

Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells.

View Full Paper
Ask AI
Bookmark
Share

Key result

During defibrillation-strength shocks, large transmembrane potential changes occurred at the ends of isolated rabbit ventricular myocytes, which were correlated with cell size and electric field strength.

Population

Isolated rabbit ventricular myocytes

Design

Preclinical

Authors

SKStephen B. KnisleyUniversity of North Carolina at Chapel HillTBTimothy F. BlitchingtonDuke Medical CenterBHBruce C. HillUniversity of Utah

Discussion

Loading...

Member takes

Implication

Shock-induced polarization at myocyte ends seen in vitro; leaves open relevance to clinical defibrillation mechanisms.

Structured PICO

P
Population
Isolated rabbit ventricular myocytes evaluated for transmembrane potential changes during defibrillation-strength shocks.
I
Intervention
Constant-field shock (S2 pulse) with an electric field of 20 or 40 V/cm given at an S1-S2 interval of 50 msec
O
Outcome
Transmembrane potential change at the cell end (delta Vm) relative to the amplitude of the S1-induced action potential (APA)surrogate

Defibrillation-strength electric field stimulation produces large transmembrane potential changes at the ends of ventricular cells, which may be sufficient to activate or recover voltage-dependent ion channels.

Cite This Study

Knisley et al. (1993) studied Isolated rabbit ventricular myocytes. Constant-field shock (electric field stimulation) was evaluated on Transmembrane potential changes (delta Vm/APA). During defibrillation-strength shocks, large transmembrane potential changes occurred at the ends of isolated rabbit ventricular myocytes, which were correlated with cell size and electric field strength.

synapsesocial.com/papers/6a6c210847a1bfb288f36aeehttps://doi.org/10.1161/01.res.72.2.255
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes.1985 · 228 citations
  2. 2Stimulus-induced critical point. Mechanism for electrical initiation of reentry in normal canine myocardium.1989 · 388 citations
  3. 3Depolarization-induced calcium uptake by vesicles in a highly enriched sarcolemma preparation from canine ventricle.1980 · 23 citations
  4. 4A simple device for rapidly exchanging solution surrounding a single cardiac cell1989 · 52 citations
  5. 5Dispersion of Repolarization Induced by a Nonuniform Shock Field1991 · 15 citations