Transmembrane Voltage Changes During Unipolar Stimulation of Rabbit Ventricle

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Population

Isolated perfused rabbit hearts stained with the potentiometric dye di-4-ANEPPS (n=7)

Comparison

Unipolar stimulation from a point electrode on… vs Cathodal versus anodal stimulation, and…

Design

Preclinical

Authors

Discussion

In vitro polarization patterns are hypothesis-generating; leaves open relevance to clinical arrhythmia management.

Population

Isolated perfused rabbit hearts stained with the potentiometric dye di-4-ANEPPS (n=7)

Intervention

Unipolar stimulation (0.1 to 40 mA) from a point electrode on the left or right ventricle

Comparator

Cathodal versus anodal stimulation, and stimulation during refractory period versus diastole

Outcome

Transmembrane voltage changes (delta Vm) recorded by Vm-sensitive fluorescencesurrogate

Stephen B. Knisley (1995) studied this question.

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