Key result
An increase in temperature increases active force production in mammalian striated muscle by shifting the thin filament state equilibrium toward the 'on' state.
Why the study?
Recent studies revealed that the thin filament state is influenced by temperature, warranting a review of how temperature affects mammalian striated muscle contractile performance.
Answers are grounded in this paper and cite their sources.
This review highlights that temperature increases active force production in mammalian striated muscle by shifting the thin filament equilibrium toward the 'on' state.
In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on-off” equilibrium of the thin filament state toward the “on” sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; viz., an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the “on-off” equilibrium of the thin filament state.
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Ishii et al. (2020) conducted a review in Striated muscle contraction. Temperature was evaluated. An increase in temperature increases active force production in mammalian striated muscle by shifting the thin filament state equilibrium toward the 'on' state.
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