Population
Mammalian muscle (fast, slow, and cardiac)
Comparison
Temperature changes vs Baseline temperature
Design
Review
Key result
Warming mammalian muscle from <10 °C to >30 °C substantially increases isometric force due to the endothermic nature of crossbridge force generation in the acto-myosin ATPase cycle.
Authors
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May affect contractility assessments in cooled states; leaves open cardiac translation pending targeted studies.
Crossbridge force generation in mammalian muscle is endothermic, leading to increased isometric force at higher temperatures.
K. W. Ranatunga (2018) conducted a review in Mammalian muscle physiology. Temperature changes was evaluated on Muscle force development and actin-myosin interaction. Warming mammalian muscle from <10 °C to >30 °C substantially increases isometric force due to the endothermic nature of crossbridge force generation in the acto-myosin ATPase cycle.