Population
Single fibres from frog skeletal muscle
Comparison
Raising the temperature (from 2 to 17 degrees C) vs Lower temperature (2 degrees C)
Design
Preclinical
Authors
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Hypothesis-generating for thermal effects on myosin mechanics; leaves open translation to mammalian cardiac muscle.
In frog skeletal muscle, raising temperature increases isometric force and myosin head strain without affecting the maximum extent of filament sliding.
Piazzesi et al. (2003) studied this question.
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