Key result
Cooling sheep cardiac sarcoplasmic reticulum calcium-release channels from 23°C to 5-10°C increased open probability from 0.13 to 0.69 at 10 microM calcium, increasing calcium current.
Population
Sheep isolated cardiac junctional sarcoplasmic reticulum membranes incorporated into planar phospholipid…
Comparison
Temperature variation vs Baseline temperature (e.g., 23 or 32 degrees C)
Design
Preclinical
Authors
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May influence calcium handling during hypothermia; leaves open relevance to human cardiac physiology.
Absolute Event Rate: 0.69% vs 0.13%
Cooling increases calcium current through sarcoplasmic reticulum calcium-release channels, providing a mechanism for rapid cooling contractures in mammalian cardiac muscle.
Sitsapesan et al. (1991) studied this question. Temperature reduction (cooling) vs. 23 degrees C was evaluated on Channel open probability (Po) at 10 microM calcium. Cooling sheep cardiac sarcoplasmic reticulum calcium-release channels from 23°C to 5-10°C increased open probability from 0.13 to 0.69 at 10 microM calcium, increasing calcium current.
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