Key result
Porcine left ventricular extract produced a maximum positive inotropic response of 501 +/- 20% in canine right ventricular trabeculae without producing aftercontractions.
Population
Canine right ventricular trabeculae
Comparison
Porcine left ventricular extract vs Control muscle and ouabagenin
Design
Preclinical
Authors
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May support novel inotrope development from cardiac extracts; leaves open translation to in vivo or human settings.
Porcine left ventricular extract produces a positive inotropic response in canine ventricular muscle, likely by increasing trans-sarcolemmal calcium influx, without causing aftercontractions.
Navaratnam et al. (1990) studied this question. Porcine left ventricular extract vs. Control muscle / Ouabagenin was evaluated on Maximum inotropic response. Porcine left ventricular extract produced a maximum positive inotropic response of 501 +/- 20% in canine right ventricular trabeculae without producing aftercontractions.
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