Population
Dog trabeculae (ventricular muscle)
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open the contribution of intracellular versus transsarcolemmal cation fluxes to human myocardial contraction.
This preclinical study demonstrates that in strontium-treated ventricular muscle, the early contraction phase is driven by intracellular cation release, while the late phase is driven by trans-sarcolemmal strontium entry.
King et al. (1983) studied this question.
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