November 1, 1975The Journal of PhysiologyOpen Access

Some electrical and mechanical effects of strontium on toad ventricular muscle: comparison to calcium.

View Full Paper

Ask AI

Bookmark

Population

Isolated, electrically driven toad ventricular muscle strips

Comparison

Strontium at concentrations from 2 mM to 10 mM vs Calcium at concentrations from 2 mM to 10 mM

Design

Preclinical

Authors

BBBG Bass ECElizabeth M. CiullaAlbert Einstein College of Medicine PKPaul Klop

Discussion

Member takes

Implication

Distinguishes Ca/Sr effects on contraction versus membrane potential in amphibian myocardium; hypothesis-generating for mammalian excitation-contraction studies.

Structured PICO

Population

Isolated, electrically driven toad ventricular muscle strips

Intervention

Strontium (Sr) at concentrations from 2 mM to 10 mM

Comparator

Calcium (Ca) at concentrations from 2 mM to 10 mM (control 2 mM)

Outcome

Mechanical effects (maximal dT/dt, maximal dL/dt, force-velocity curves) and electrophysiological effects (transmembrane action potential duration)surrogate

Strontium and calcium act similarly in activating contraction in toad ventricular muscle but have differing effects on the cell membrane action potential duration.

Cite This Study

Bass et al. (1975) studied this question.

synapsesocial.com/papers/6a729bfc87f9210571289e89 https://doi.org/10.1113/jphysiol.1975.sp011158

View Full Paper

Ask AI

Bookmark

Implication

Distinguishes Ca/Sr effects on contraction versus membrane potential in amphibian myocardium; hypothesis-generating for mammalian excitation-contraction studies.

Some electrical and mechanical effects of strontium on toad ventricular muscle: comparison to calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Some electrical and mechanical effects of strontium on toad ventricular muscle: comparison to calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider